A new research reveals that a stress coping hormone released by the brain has side effects which may lead to Alzheimer’s disease. The stress coping hormone called CRF boosts the production of protein fragments known as amyloid beta which clump together and trigger the brain degeneration that leads to Alzheimer’s disease, the research revealed.
The University of Florida Health researchers conducted the study on a mouse model and in human cells. Alzheimer’s believed to stem from a mix of genetic lifestyle and environmental factors. “ Our study adds detailed insight into the stress mechanisms that might promote at least one of the Alzheimer’s pathologies” study co author professor Todd Golde said.
The study found that stress causes the release of a hormone called corticotrophin releasing factor or CRF in the brain. That in turn increases production of amyloid beta. As amyloid beta collects in the brain it initiates a complex degenerative cascade that leads to Alzheimer’s disease.
The researchers treated human neurons with CRF. That caused a significant increase in the amyloid proteins involved in Alzheimer’s disease. Those and other complex experiments reveal more about the mechanics of a likely relationship between stress and Alzheimer’s disease. The findings were published in THE EMBO journal
Courtesy THE HINDU